|
KMID : 1161420140170050550
|
|
Journal of Medicinal Food
2014 Volume.17 No. 5 p.550 ~ p.557
|
|
|
Quercetin Suppresses MIP-1α?Induced Adipose Inflammation by Downregulating Its Receptors CCR1/CCR5 and Inhibiting Inflammatory Signaling
|
|
Noh Hye-Ji
Kim Chu-Sook
Kang Ji-Hye
Park Jun-Young
Choe Suck-Young
Hong Soon-Myoung
Yoo Hoon
Park Tae-Sun
Yu Ri-Na
|
|
|
Abstract
|
|
|
|
Obesity-induced inflammation is characterized by recruitment of adipose tissue macrophages that release inflammatory cytokines and chemokines. MIP-1α (macrophage inflammatory protein 1α)/CCL3, a CC chemokine, induces monocyte/macrophage infiltration and thus is implicated in obesity-induced adipose inflammation. Quercetin has been shown to modulate obesity-induced inflammation, but the mechanism of its action remains unclear. Here we demonstrate that quercetin decreases MIP-1α release from adipocytes and macrophages and from cocultured adipocytes/macrophages; it also opposes MIP-1α?induced macrophage infiltration and activation. The inhibitory action of quercetin on the MIP-1α?induced inflammatory responses of macrophages is mediated by downregulation of CCR1/CCR5, and inhibition of activation of JNK, p38 mitogen-activated-protein kinase (MAPK), and IKK as well as IκBα degradation. These findings suggest that quercetin may be a useful agent against obesity-induced adipose tissue inflammation.
|
|
|
KEYWORD
|
|
|
adipose tissue, chemokine, inflammation, obesity, quercetin
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|